WebNov 13, 2024 · Background: CC-90009 is a cereblon (CRBN) E3 ligase modulator (CELMoD) and a first-in-class small molecule that drives the binding of a novel target protein, G1 to S phase transition 1 (GSPT1), to … WebNov 11, 2024 · GSPT1 degraders lit up — and proved to have cancer-killing capabilities when subsequently screened in over 500 cancer cell lines and 80 xenograft models of disease. The company has been hard at...
ORM-6151: A First-in-Class, Anti-CD33 Antibody-Enabled GSPT1 Degrader ...
WebJul 14, 2016 · Abstract. Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate specificity on the CRL4 (CRBN) E3 ubiquitin ligase. Here we report the identification of a new cereblon modulator, CC-885, with potent anti-tumour activity. The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination … WebJan 17, 2024 · ORM-5029, the latest disclosed DAC or Antibody neoDegrader Conjugate (AnDC™), aims to deliver a GSPT1 degrader (Smol006) to HER2-expressing cells via pertuzumab. This AnDC™ has demonstrated stronger cytotoxicity than other GSPT1 degraders and anti-tumor activity comparable to that of DS-8201a . The toxicity of ORM … gifts for 15 year old girls for christmas
The Effects of GSPT1 Degradation on Serum Calcium, Parathyroid …
WebMar 14, 2024 · Poster Title: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML. Date and Time: Monday, April 17, 1:30PM - 5:00PM ET. Session … WebMar 18, 2024 · GSPT1 degrader. Acute myeloid leukaemia. Phase I. CC-92480. Bristol Myers Squibb. ... “This is a first test of whether we can use a degrader to overcome on … WebFurther analysis revealed that SJPYT-195 was a molecular glue degrader of the translation termination factor GSPT1 and that GSPT1 degradation resulted in subsequent reduction of PXR protein. GSPT1 has recently … f scott fitzgerald mug